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Salah Massoud, Ph.D.

Professor

Montgomery Hall, Room 220

P.O. Box 43700
Lafayette LA 70504
337-482-5672
ssmassoud@louisiana.edu

Education:

Ph.D. (Inorganic/Bioinorganic Chemistry), Boston University, Boston, MA, 1985
M.Sc. (Inorganic Chemistry), Alexandria University, Egypt, 1978
B.Sc. (Chemistry, Distinction with Hons.), Alexandria University, Egypt, 1974

Professional Bibliography

Research Interests:

Dr. Massoud’s research focuses on coordination chemistry relevant to biological systems and material sciences. This includes:

  • DNA Cleavage: We are interesting in synthesizing highly reactive artificial nucleases that can rapidly and selectively catalyze the cleavage of the P-O bonds in DNA and phosphodiesters under physiologicl conditions. A large number of mono and dinuclear Co(II) and Cu(II) complexes derived from pyridyl tripod amines and phenolic binucleating ligands were synthesized and characterized, and their catalytic hydrolysis in promoting the DNA cleavage as well as phosphodiester hydrolysis are tested.
     
  • Anticancer Compounds: The search for an effective therapeutic anti-tumor compounds requires lowering the therapeutical dosage of the drug and also reducing its toxicity. To achieve this target we testing a new series Cu(II) and Co(II) based different tripod amines that derived from heterocyclic bases such as pyrzolyl  and imidazolyl groups.
     
  • Carbon Dioxide Fixation: Recently, we have been involved in the synthesis of a series of polynuclear metal(II) complexes that efficiently can absorb the atmospheric CO2 from the air and convert it into carbonate that bridges several metal ions that can serve as the green chlorophyll and hence reduce the global warming.
We are also interested in the design of inorganic molecules of novel magnetic properties that can utilizes some applications in Material Sciences; Single Molecular Magnets (SMM) and Field-Induced Single-Ion Magents (SIMs) which have important applications in ultra-high density magnetic information storage.  The strategy for synthesizing these compounds depends on the assembly of paramagnetic centers (Cu2+, Ni2+, Co2+) via bridging ligands. Other compartmental ligands accommodate two metal ions or more that can act as bridging ligands.  These ligands are used to synthesize polynuclear 3d-3d and 3d-4f metal ions.


Selected Publications:

A Complete List of Publications is also available.

  • Massoud, S. S.; Ledet, C. C.; Junk, T.; Bosch, S.; Comba, P.; Herchel, R.; Hošek, J.; Trávníček, Z.; Fischer, R. C.; Mautner, F. A. Dalton Trans. 2016, 45, 12933-12950. “Dinuclear Metal(II)-acetato Complexes Based on Bicompartmental 4-Chlorophenol: Synthesis, Structure, Magnetic Properties, DNA Interaction and Phosphodiester Hydrolysis”.
     
  • Herchel, R.; Dvořák, Z.; Trávníček, Z.; Mikuriya, M.; Louka, F. R.; Mautner, F. A.; Massoud, S. S. Inorg. Chim. Acta 2016, 451, 102-110. “Cobalt(II) and Copper(II) Covalently and Non-covalently Dichlorido-bridged Complexes of an Unsymmetrical Tripodal pyrazolyl-pyridyl Amine Ligand: Structures, Magnetism and Cytotoxicity”.
     
  • Mautner, F. A.; Fischer, R. C.; Tran, D. H.; Acevedo,  A. R.; Massoud, S. S. Crystals, 2016, 6, 19 (invited). “Metal(II) Complexes of Compartmental Polynuclear Schiff Bases Containing Phenolate and Alkoxy Groups”.
     
  • Massoud, S. S.; Louka F. R.; Gazzaz, M.; Henary, M. M.; Fischer, R. C.; Mautner, F. A. Polyhedron, 2016, 111, 45-52. “Polynuclear Copper(II) Complexes Bridged by Polycarboxylates of Aromatic and N-heterocyclic Compounds”.
     
  • Massoud, S. S.;  Spell, M.; Ledet, C.; Junk, T.; Herchel, R.; Fischer, R. C.; Travnicek, Z.; Mautner, F. A. Dalton  Trans., 2015, 44, 2110-2121. “Magnetic and Structural Properties of Dinuclear Singly Bridged-Phenoxido Metal(II) Complexes”.
     
  • Massoud, S. S.; Junk, T.;  Louka, F. R.; Herchel, R.; Travnicek, Z.; Fischer R. C.; Mautner, F. A. RSC Advances, 2015, 5, 87139-87150. “Synthesis, Structure and Magnetic Characterization of Dinuclear Copper(II) Complexes Bridged by  Bicompartmental Phenolate”.
     
  • Massoud, S. S.; Louka, F. R.; Mautner, F. A. CrystEngComm, 2015, 17, 7604-7617 (Review article). “Polynuclear and Polymeric Squarato-Bridged Metal(II) Complexes”.
     
  • Massoud, S. S.; Louka, F. R.; Al-Hasan, M. A.; Vicente, R.; Mautner, F. A. New J. Chem., 2015, 39, 5944-5952. “Magneto-structural Properties of Carbonato-bridged Copper(II) Complexes. Fixation of Atmospheric CO2”.
     
  • Massoud, S. S.; Perkins, R. S.; Louka, F. R.; Xu, W.; Le Roux, A.; Dutercq, Q.; Fischer, R. C.;  Mautner, F. A.; Handa, M.; Hiraoka, Y.; Kreft, G. L.;  Bortolotto, T.; Terenzi, H., Dalton Trans. 2014, 43, 10086-10103.“Efficient Hydrolytic Cleavage of Plasmid DNA by Chloro-cobalt(II) Complexes Based on Sterically Hindered Pyridyl Tripod Tetraamine Ligands: Synthesis, Crystal Structure and DNA Cleavage Activity”.
     
  • Massoud, S. S.; Junk, T.; Mikuriya, M.; Naka, N.; Mautner, F. A., Inorg. Chem. Commun., 2014, 50, 48-50. “Synthesis, Structure and Magnetic Characterization of Dinuclear Copper(II) Complexes of 2,6-Bis[bis(pyridine-2-ylmethyl)aminomethyl]-4-methylpyridine”.
     
  • Massoud, S. S.; Taylor, E.; Liu, Y.; Grebowicz, J.; Vicente, R.; Lalancette, R.; Mukhopadhyay, U.; Bernal, I., Watkins, S. F. CrystEngComm. 2014, 16, 175-183. “Synthesis, Structure,
    Thermal, Magnetic Properties and Quantum Mechanical Calculations of Bridged [Bis(di(2-pyridylmethyl)amine)-(μ2-1,2-bis(4-pyridyl)ethane)-tetraperchlorato-dicopper(II)] Dihydrate Complex (I)”.
     
  • Mautner, F. A.; Louka, F. R.; Hofer, J.; Spell, M.; Lefèvre, A.; Guilbeau, A. E.; Massoud, S. S. Crystal Growth & Design 2013, 13, 4518-4525. “One-Dimensional Cadmium Polymers with Alternative di(EO/EE) and di(EO/EO/EO/EE) Bridged Azide Bonding Modes”.
     
  • Massoud, S. S.; Louka, F. R.; Obaid, Y. K.; Vicente, R.; Ribas, J.; Fischer, R. C.; Mautner, F. A. Dalton Trans. 2013, 42, 3968-3978. “Metal ions Directing the Geometry and Nuclearity of Azido-metal(II) Complexes Derived from Bis(2-(3,5-dimethyl-1H-pyrazol-1-yl)ethyl)amine”.  
     
  • Massoud, S. S.; Louka, F. R.; Xu, W.; Perkins, R.; Vicente, R.; Albering, J. H.; Mautner, F. A. Eur. J. Inorg. Chem. 2011, 3469-3479.  “DNA Cleavage by Structurally Characterized Dinuclear Copper(II) Complexes Based on Triazine”.
     
  • Mautner, F. A.; Albering, J. H.; Corbella, M.; Louka, F. R.; Massoud, S. S. Inorg. Chem. Commun. 2011, 14, 702-705. “A Unique Unit Cell Containing Simultaneous Doubly and Triply Copper(II) Complexes Bridging by 2,4-Pyridine Dicarboxylate.  Synthesis, Structural Characterization and Magnetic Properties” .
     
  • Massoud, S. S.; Louka, F. R; Mikuriya, M.; Ishida, H.; Mautner, F. A., Inorg. Chem. Commun. 2009 12, 420-425. “Dicyanamido-metal(II) Complexes: Hydrolysis of the Dicyanamide into Amidocyanamide During its Interaction with Cu(II) Perchlorate and 2-Pyridylcarbonyl-N,N-bis(2-pyridylmethyl)amine”.
     
  • Massoud, S. S.; Mautner, F. A.; Vicente, R.; Louka, F. R. Eur. J. Inorg. Chem. 2008, 3709-3717. “Squarato-metal(II) Complexes: μ1,3- (trans) and μ1,2- (cis) Bonding in Squarato-Bridged Dinuclear Copper(II) and Nickel(II) Complexes Derived from Polypyridyl Amines”.
     
  • Vicente, R.; Ruiz, E.; Cano, J.; Massoud, S. S.; Mautner, F. A. Inorg. Chem. 2008, 47, 4648-4655. “Squarato-Metal(II) Complexes. 2. Unusual Bonding Mode for a Squarato-Bridged Trinuclear Copper(II) Complex”.