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Salah Massoud, Ph.D.

Professor

Montgomery Hall, Room 220

P.O. Box 43700
Lafayette LA 70504
337-482-5672
ssmassoud@louisiana.edu

Education:

Ph.D. (Inorganic/Bioinorganic Chemistry), Boston University, Boston, MA, 1985
M.Sc. (Inorganic Chemistry), Alexandria University, Egypt, 1978
B.Sc. (Chemistry, Distinction with Hons.), Alexandria University, Egypt, 1974

Professional Bibliography

Research Interests:

Dr. Massoud’s research focuses on coordination chemistry relevant to biological systems and material sciences. This includes:

  • DNA Cleavage: We are interesting in synthesizing highly reactive artificial nucleases that can rapidly and selectively catalyze the cleavage of the P-O bonds in DNA and phosphodiesters under physiologicl conditions. A large number of mono and dinuclear Co(II) and Cu(II) complexes derived from pyridyl tripod amines and phenolic binucleating ligands were synthesized and characterized, and their catalytic hydrolysis in promoting the DNA cleavage as well as phosphodiester hydrolysis are tested.
     
  • Anticancer Compounds: The search for an effective therapeutic anti-tumor compounds requires lowering the therapeutical dosage of the drug and also reducing its toxicity. To achieve this target we testing a new series Cu(II) and Co(II) based different tripod amines that derived from heterocyclic bases such as pyrzolyl  and imidazolyl groups.
     
  • Carbon Dioxide Fixation: Recently, we have been involved in the synthesis of a series of polynuclear metal(II) complexes that efficiently can absorb the atmospheric CO2 from the air and convert it into carbonate that bridges several metal ions that can serve as the green chlorophyll and hence reduce the global warming.
We are also interested in the design of inorganic molecules of novel magnetic properties that can utilizes some applications in Material Sciences; Single Molecular Magnets (SMM) and Field-Induced Single-Ion Magents (SIMs) which have important applications in ultra-high density magnetic information storage.  The strategy for synthesizing these compounds depends on the assembly of paramagnetic centers (Cu2+, Ni2+, Co2+) via bridging ligands. Other compartmental ligands accommodate two metal ions or more that can act as bridging ligands.  These ligands are used to synthesize polynuclear 3d-3d and 3d-4f metal ions.


Selected Publications:

A Complete List of Publications is also available.

  • Massoud, S. S.; Louka, F. R.; Tusa, A.F.; Bordelon, N. E.; Fischer, R. C.; Mautner, F. A.; Vančo, J.; Hošek, J.; Dvořákd, Z.; Trávníček, Z. New J. Chem. 2019, 43, 6186-6196. DOI: 10.1039/C9NJ00061E  “Copper(II) Complexes Based on Tripodal Pyridyl-amine Derivatives as Efficient Anticancer Agents”.
     
  • Mautner, F. A.; Fischer, R. C.; Torvisco,  A.; Henary, M. M.; Milner A.; DeVillier, H.; Karsili, T. N. V.; Louka, F. R.; Massoud, S. S. Crystals 2019, 9, 38.  doi:10.3390/cryst9010038  “Steric Effects of Alkyl Substituents at N-Donor Bidentate Amines Direct the Nuclearity, Bonding and   Bridging Modes in Isothiocyanato-Copper(II) Coordination Compounds”.
     
  • Mautner, F. A.; Jantscher, P.; Fischer, R. C.; Torvisco, A.; Vicente, R.; Karsili, T. N. V.; Massoud, S. S., Polyhedron 2019, 1166, 34-43. https://doi.org/10.1016/j.poly.2019.03.038 “Synthesis and Characterization of 1D Coordination Polymers of Metal(II)-dicyanamido Complexes”.
     
  • Mautner, F. A.; Traber, M.; Jantscher, P.; Fischer, R. C.; Reichmann, K.; Vicente, R.; Arafat, N.; Massoud, S. S. Polyhedron 2019, 161, 309-316. “Thiocyanato-metal(II) and Azido-cobalt(III) Complexes with Hydroxymethylpyridines”.
     
  • Mautner, F. A.; Fischer , R. C.; Reichmann, K.; Gullett, E., Ashkar, K.; Massoud, S. S. J. Mol. Struct. 2019, 1175, 797-803. DOI:10.1016/j.molstruc.2018.08.022 “Synthesis and Characterization of 1D and 2D Cadmium(II)-2,2'-bipyridine-N,N'-dioxide Coordination Polymers Bridged by Pseudohalides”.
     
  • Mautner, F. A.; Traber, M.; Fischer, R. C.; Torvisco, A.; Reichmann, K.; Speed, S.; Vicente, R.; Massoud, S. S. Polyhedron 2018, 154, 436-442. DOI.org/10.1016/j.poly.2018.08.022 “Synthesis and Structural Characterization of Thiocyanato-4-methoxypyridine-cobalt(II) Complexes with       Diverse Geometries and a Bridged 1D Coordination Polymer showing Metamagnetic Transition”.
     
  • Kettenmann, S. D.; Louka, F. R.; Marine, E.; Fischer, R. C.; Mautner, F. A.; Kulak, N.; Massoud, S. S. Eur. J. Inorg. Chem. 2018, 2322-2338. DOI: 10.1002/ejic.201800276 “Efficient Artificial Nucleases for Mediating DNA Cleavage Based on Tuning the Steric Effect in the Pyridyl Derivatives of Tripod Tetraamine-cobalt(II) Complexes”.
     
  • Massoud, S. S.; Henary, M. M.;  Maxwell, L.; Martín, A.; Ruiz, E.; Vicente, R.; Fischer, R. C.; Mautner, F. A.  New J. Chem. 2018, 42, 2627-2639. DOI:10.1039/c7nj04150k “Structure, Magnetic Properties and DFT Calculations of Azido-Copper(II) Complexes with Different Azido-bonding, Nuclearity and Dimensionality”.
     
  • Massoud, S. S.; Louka, F. R.; Ducharme, G. T.; Fischer, R. C.;  Mautner, F. A.; Vančo, J.; Herchel, R.;  Dvořák, Z.; Trávníček, Z. J. Inorg. Biochem. 2018, 180, 39-46. https://doi.org/10.1016/j.jinorgbio.2017.11.02 “Copper(II) Complexes Based on Tripodal Pyrazolyl   Amines: Synthesis, Structure, Magnetic Properties and Anticancer Activity”.
     
  • Massoud, S. S.; Fischer, R. C. Mautner, F. A.; Parfait, M. M.; Herchel, R.; Trávníček. Z. J. Inorg. Chim. Acta 2018, 471, 630-639. https://doi.org/10.1016/j.ica.2017.11.036 “Pentacoordinate Cobalt(II) Complexes with Neutral Tripodal N-Donor Ligands Exhibiting Slow Relaxation of Magnetism”.
     
  • Mautner, F. A.; Berger, C.; Fischer, R. C.; Massoud, S. S.; Vicente, R. Polyhedron 2018, 141, 17-24. https://doi.org/10.1016/j.poly.2017.11.022 “Synthesis, Structural Characterization and Magnetic Properties of Mn(II) Isothiocyanate Complexes Based  on Pyridine-N-oxide Derivative Co-ligands”.
     
  • Massoud, S. S.; Williams, G. F.; Louka, F. R.; Henary, M. M.; Herchel, R.; Trávníček, Z.; Fischer,  R. C. Mautner, F. A. New J. Chem. 2017, 41, 3846-3856. Doi: 10.1039/C6NJ03943J “Croconato-bridged Copper(II) Complexes. Synthesis, Structure and Magnetic Characterization”.
     
  • Mautner, F. A., Fischer, R. C.; Rashmawi, L. G.; Louka, F. R.; Massoud, S. S. Polyhedron 2017, 124, 237-242. Doi: 10.1016/j.poly.2017.01.001 “Structural Characterization of Metal(II) Thiocyanato Complexes Derived from Bis(2-(1-H- pyrazol-1-yl)ethyl)-amine”.
     
  • Mautner, F. A.; Fischer, R. C.; Tran, D. H.; Acevedo,  A. R.; Massoud, S. S. Crystals 2016, 6, 91 (invited). doi:10.3390/cryst6080091. http://www.mdpi.com/2073-4352/6/8/91 “Metal(II) Complexes of Compartmental Polynuclear Schiff Bases Containing Phenolate and Alkoxy Groups”.
     
  • Massoud, S. S.; Ledet, C. C.; Junk, T.; Bosch, S.; Comba, P.; Herchel, R.; Hošek, J.; Trávníček, Z.; Fischer, R. C.; Mautner, F. A. Dalton Trans. 2016, 45, 12933-12950. DOI: 10.1039/C6DT02596J “Dinuclear Metal(II)-acetato Complexes Based on Bicompartmental 4-Chlorophenol: Synthesis, Structure, Magnetic Properties, DNA Interaction and Phosphodiester Hydrolysis”.
     
  • Herchel, R.; Dvořák, Z.; Trávníček, Z.; Mikuriya, M.; Louka, F. R.; Mautner, F. A.; Massoud, S. S. Inorg. Chim. Acta 2016, 451, 102-110. http://dx.doi.org/10.1016/j.ica.2016.06.030 “Cobalt(II) and Copper(II) Covalently and Non-covalently Dichlorido-bridged Complexes of an Unsymmetrical Tripodal pyrazolyl-pyridyl Amine Ligands: Structures, Magnetism and Cytotoxicity”.
     
  • Massoud, S. S.; Louka F. R.; Gazzaz, M.; Henary, M. M.; Fischer, R. C.; Mautner, F. A. Polyhedron 2016, 111, 45-52. http://dx.doi:10.1016/j.poly.2016.03.013 “Polynuclear Copper(II) Complexes Bridged by Polycarboxylates of Aromatic and N-heterocyclic".
     
  • Mautner, F. A.; Berger, C.; Fischer, R. C.; Massoud, S. S. Inorg. Chim. Acta 2016, 439, 69-76. “Synthesis, Characterization and Luminescence Properties of Zinc(II) and Cadmium(II) Pseudohalide Complexes Derived from Quinoline-N-oxide”.
     
  • Massoud, S. S.; Junk, T.;  Louka, F. R.; Herchel, R.; Travnicek, Z.; Fischer R. C.; Mautner, F. A. RSC Adv. 2015, 5, 87139-87150. DOI: 10.1039/c5ra19358c “Synthesis, Structure and Magnetic Characterization of Dinuclear Copper(II) Complexes Bridged by  Bicompartmental Phenolate”.
     
  • Massoud, S. S.; Louka, F. R.; Mautner, F. A. CrystEngComm, 2015, 17, 7604-7617 (Invited). DOI: 10.1039/C5CE01322D “Polynuclear and Polymeric Squarato-Bridged Metal(II) Complexes”. 
     
  • Massoud, S. S.; Junk, J.; Herchel, R.; Travnicek, Z.; Mikuriya, M.; Fischer, R. C.;  Mautner, F. A. Inorg. Chem. Commun., 2015, 60, 1-3. http://dx.doi.org/10.1016/j.inoche.2015.07.010 “Structural Characterization of Ferromagnetic Bridged-Acetato and-Dichlorido Copper(II) Complexes Based on Bicompartmental 4-t-Butylphenol”.
     
  • Massoud, S. S.; Louka, F. R.; Al-Hasan, M. A.; Vicente, R.; Mautner, F. A. New J. Chem., 2015, 39, 5944-5952. http://dx.DOI: 10.1039/C5NJ00285K “Magneto-structural Properties of Carbonato-bridged Copper(II) Complexes. Fixation of Atmospheric CO2”.
     
  • Massoud, S. S.; Louka, F. R.; David, R. N.; Dartez, M. J.; Nguyn, Q. L.; Labry, N. J.; Fischer, R. C.; Mautner, F. R. Polyhedron, 2015, 90, 258-265. http://dx.doi: 10.1016/j.poly.2015.02.014 “Five-coordinate Thiocyanato- and Azido-metal(II) Complexes Based Pyrazolyl Ligands”.
     
  • Massoud, S. S.;  Spell, M.; Ledet, C.; Junk, T.; Herchel, R.; Fischer, R. C.; Travnicek, Z.; Mautner, F. A. Dalton Trans., 2015, 44, 2110-2121. http://dx.DOI: 10.1039/C4DT03508A  “Magnetic and Structural Properties of Dinuclear Singly Bridged-Phenoxido Metal(II) Complexes”.
          
  • Mautner, F. A.; Scherzer, M.; Berger, C.; Fischer, R. C.; Massoud, S. S. Inorg. Chim. Acta 2015, 425, 46-51.  http://dx.doi:10.1016/j.ica.2014.10.018 “Synthesis, Characterization and Luminescence Properties of Zinc(II) Complexes of Pseudohalides and Nitrite Derived from 4-Azido-pyridine”.
     
  • Mautner, F. A.; Scherzer, M.; Berger, C.; Fischer, R. C.; Vicente, R.; Massoud S. S. Polyhedron 2015, 85, 329-336. http://dx.doi: 10.1016/j.poly.2014.08.012 “Synthesis and Characterization of Three New 1-D Polymeric [M2(4-azidopyridine)4(µ1,1-N3)2(µ1,3-N3)2]n (M = Ni, Co, Cd) Complexes”.
     
  • Massoud, S. S.; Junk, T.; Mikuriya, M.; Naka, N.; Mautner, F. A. Inorg. Chem. Commun. 2014, 50, 48-50. http://dx.doi:10.1016/j.inoche.2014.10.027 “Synthesis, Structure and Magnetic Characterization of Dinuclear Copper(II) Complexes of 2,6-Bis[bis(pyridine-2-ylmethyl)aminomethyl]-4-methylpyridine”.
     
  • Massoud, S. S.; Perkins, R. S.; Louka, F. R.; Xu, W.; Le Roux, A.; Dutercq, Q.; Fischer, R. C.;  Mautner, F. A.; Handa, M.; Hiraoka, Y.; Kreft, G. L.;  Bortolotto, T.; Terenzi, H. Dalton Trans. 2014, 43, 10086-10103. http://dx.doi:10.1039/C4DT00615A “Efficient Hydrolytic Cleavage of Plasmid DNA by Chloro-cobalt(II) Complexes Based on Sterically Hindered Pyridyl Tripod Tetraamine Ligands: Synthesis, Crystal Structure and DNA Cleavage Activity”.
     
  • Massoud, S. S.; Gallo, A. A.; Dartez, M. J.; Gautreaux, J. G.; Ramon Vicente, R.; Albering, J. H.; Mautner, F. A. Inorg. Chem. Commun. 2014, 43, 35-38. http://dx.doi.org/10.1016/j.inoche.2014.02.004 “Dinuclear Copper(II) Complexes Bridged by Imidazole-3,5-dicarboxylate”
     
  • Mautner, F. A.; Berger, C.; Dartez, M. J.; Nguyen, Q. L.; Favreau, J.; Massoud, S. S. Polyhedron 2014, 69, 48-54. http://dx.doi:10.1016/j.poly.2013.11.019. “Cadmium(II) and Zinc(II) Azido Complexes with Different Nuclearity and Dimensionality”.
     
  • Massoud, S. S.; Taylor, E.; Liu, Y.; Grebowicz, J.; Vicente, R.; Lalancette, R.; Mukhopadhyay, U.; Bernal, I., Watkins, S. F. CrystEngComm. 2014, 16, 175-183.  http://dx.doi:10.1039/C3CE41821A. “Synthesis, Structure, Thermal, Magnetic Properties and Quantum Mechanical Calculations of Bridged [Bis(di(2-pyridylmethyl)amine)-(μ2-1,2-bis(4-pyridyl)ethane)-tetraperchlorato-dicopper(II)] Dihydrate Complex (I)”
     
  • Mautner, F. A.; Louka, F. R.; Hofer, J.; Spell, M.; Lefèvre, A.; Guilbeau, A. E.; Massoud, S. S. Cryst. Growth Des. 2013, 13, 4518-4525. http://dx.doi.org/10.1021/cg400998r “One-Dimensional Cadmium Polymers with Alternative di(EO/EE) and di(EO/EO/EO/EE) Bridged Azide Bonding Modes”.
     
  • Mautner, F. A.; Koikawa, M.; Mikuriya, M.; Harrelson, E. H.; Massoud, S. S. Polyhedron 2013, 59, 17-23. http://dx.doi:10.1016/j.poly.2013.04.033 “Copper(II)-azide Complexes Constructed from Polypyridyl Amine Ligands”.
     
  • Massoud, S. S.; Guilbeau, A. E.; Luong, H. T.; Vicente, R.; Albering, J. H.; Fischer, R. C.; Mautner, F. A. Polyhedron 2013, 54, 26-33.  http://dx.doi.org/10.1016/j.poly.2013.01.033 “Mononuclear, Dinuclear and Polymeric 1-D Thiocyanato- and Dicyanamido-copper(II) Complexes Based on Tridentate Coligands”.
     
  • Massoud, S. S.; Pujol, K. J.; Mautner, F. A.; Demeshko, S.; Dechert, S.; Meyer, F. Inorg. Chem. Commun. 2013, 30, 65-68. http://dx.doi:10.10.1016/j.inoche.2013.01.012 “Squarato-metal(II) Complexes: Part 6. Synthesis, Structure and Magnetic Characterization of An Usual Squarate-Based 1D Copper(II) Coordination Polymer Composed of Hexanuclear Entities and a Trinucleating Ligand Scaffold” 
     
  • Massoud, S. S.; Vicente, R.; Fontenot, P. R.; Gallo, A. A.; Mikuriya, M.; Albering, J. H.; Mautner, F. A. Polyhedron 2012, 46, 66-73. http://dx.doi.10.1016/j.poly.2012.07.049 “Polynuclear Crocontato-bridged-Copper(II) Complexes Dreived from Tri- and Tetra-dentate Amines”.
     
  • Louka, F. R., Nguyen, L. T.; Albering, J. H.; Mautner, F. A.; Massoud, S. S. Inorg. Chem. Commun. 2012, 15, 269-271. http://dx.doi.10.1016/j.inoche.2011.10.042 “Unprecedented Formation of a Doubly Bridged μ-Peroxo-μ-pyrazolyldicarboxylatodicobalt(III) Complex”.
     
  • Massoud, S. S.; Le Quan, L.; Gatterer, K.; Albering, J. H.; Fischer, R. C.; Mautner, F. A. Polyhedron  2012, 31, 601-606. http://dx.doi.10.1016/j.poly.2011.10.011  “Structural Characterization of Five-Coordinate Copper(II), Nickel(II) and Cobalt(II) Thiocyanato Complexes Derived from Bis(2-(3,5-dimethyl-1-pyrazolyl)ethyl)amine”. 
     
  • Massoud, S. S.; Louka, F. R.; Xu, W.; Perkins, R.; Vicente, R.; Albering, J. H.; Mautner, F. A. Eur. J. Inorg. Chem. 2011, 3469-3479. http://dx.doi.10.1002/ejic.201100157 “DNA Cleavage by Structurally Characterized Dinuclear Copper(II) Complexes Based on Triazine”.
     
  • Xu, W.; Craft, J. A.; Fontenot, P. R.; Barens, M.; Knierim, K. D.; Albering, J. H.; Mautner, F. A.;  Massoud, S. S. Inorg. Chim. Acta 2011, 373,159-166. http://dx.doi.10.1016/j.ica.2011.04.012 “Effect of the Central Metal Ion on the Cleavage of DNA by [M(TPA)Cl]ClO4 Complexes (M = CoII, CuII and ZnII, TPA = tris(2-pyridylmethyl)amine). An Efficient Artificial Nuclease for DNA Cleavage”.
     
  • Louka, F. R.; Spell, M. L.; Grebowicz, J.; Albering, J. H.; Mautner, F. A.; Massoud, S. S. J. Mol. Struct. 2011, 995, 103-108. http://dx.doi.10.1016/j.molstruc.2011.03.066 “Coordination Chemistry of 1,4-Bis[bis(2-pyridylmethyl)aminomethyl]benzene with Copper(II)” 
     
  • Massoud, S. S.; Mautner, F. A.; Louka, F. R.; Demeshko, S.; Dechert, S.; Meyer, F. Inorg. Chim. Acta 2011, 370, 435-443. http://dx.doi.10.1016/j.ica.2011.02.019 “Diverse Coordination of Polynuclear Copper(II) Complexes Constructed from Benzene Tetracarboxylate”
     
  • Massoud, S. S.; Louka, F. R.; Nguyen, T. L.; Mikuriya, M.; Albering, J. H.; Mautner, F. A. Inorg. Chim. Acta 2011, 366, 394-398.  http://dx.doi.10.1016/j.ica.2010.11.014 “Structural and Magnetic Characterization of 1-D Copper Complexes Constructed from Pyrazole-3,5- dicarboxylate Bridging Multi Cu(II) Centers”.
     
  • Mautner, F. A.; Albering, J. H.; Mikuriya, M.; Massoud, S. S. Inorg. Chem. Commun. 2010, 13, 796-799. http://dx.doi.org/10.1016/j.inoche.2010.03.051 “Dicyanamido-Metal(II) Complexes. Part 5: First Example for a Unit Cell Containing Dinuclear and 1-D Polymeric Cu(II) Complexes Bridging by Dicyanamide”.
     
  • Massoud, S. S.; Druel, E.; Dufort M.; Lalancette R.; Kitchen, J.; Grebowicz, J.; Vicente, R.; Mukhopadhyay, U.; Bernal, I.; Mautner, F. A. Polyhedron 2009, 28, 3849-3857. http://dx.doi.org/10.1016/j.poly.2009.08.019 “Versatile Binding Properties of Di-pyridyl Ligands with Cu(II) Complexes. The Syntheses, Structure and Thermal Analysis of Six New Species”.
     
  • Mautner, F. A.; Mikuriya, M., Ishida, H.; Louka, F. R.; Humphrey, J. W.; Massoud, S. S. Inorg. Chim. Acta 2009, 362, 4073-4080 .http://dx.doi.org/10.1016/j.ica.2009.05.066 “Dicyanamido-Metal(II) Complexes. Part 4. Synthesis, Structure and Magnetic Characterization of Polynuclear Cu(II) and Ni(II) Complexes Bridged by μ-1,5-Dicyanamide”.
     
  • Massoud, S. S.; Louka, F. R; Mikuriya, M.; Ishida, H.; Mautner, F. A. Inorg. Chem. Commun. 2009 12, 420-425. “Dicyanamido-metal(II) Complexes. Part 3. Hydrolysis of the Dicyanamide into Amidocyanamide During its Interaction with Cu(II) Perchlorate and 2-Pyridylcarbonyl-N,N-bis(2-pyridylmethyl)amine”.
     
  • Xu, W.; Louka , F. R.; Doulain, P. E.; Landry, C. A.; Mautner, F. A.; Massoud, S. S. Polyhedron 2009, 28, 1221-1228. “Hydrolytic Cleavage of DNA Promoted by Cobalt(III)-Tetraamine Complexes. Synthesis and Characterization of Carbonatobis[2-(2-pyridylethyl)]-(2-pyridylmethyl)aminecobalt(III) Perchlorate”.
     
  • LeGuet, T.; Mautner, F. A.; Demeshko, S.; Meyer, F.; Perkins, R. S.; Massoud, S. S. Inorg. Chem. Commun. 2009, 12, 321-324. “A Novel 1-D Coordination Cu(II) Polymer with Alternating μ1,3-Squarato and Binucleating Polypyridylamine Bridges”.
     
  • Massoud, S. S.; Mautner, F. A.; Vicente, R.; Louka, F. R. Eur. J. Inorg. Chem. 2008, 3709-3717. “Squarato-metal(II) Complexes. Part 3: μ1,3- (trans) and μ1,2- (cis) Bonding in Squarato-Bridged Dinuclear Copper(II) and Nickel(II) Complexes Derived from Polypyridyl Amines”.
     
  • Louka, F. R.; Mautner, F. A.; Vicente, R.; Massoud, S. S. Inorg. Chem. Commun. 2008, 11, 438-441. “μ2-Oxalato-bridged Tri-copper(II) Complex Derived from 1,4,8,12-Tetraazacyclopentadecane. Synthesis, Structure and Magnetic Characterization”.
     
  • Vicente, R.; Ruiz, E.; Cano, J.; Massoud, S. S.; Mautner, F. A. Inorg. Chem. 2008, 47, 4648-4655. “Squarato-Metal(II) Complexes. 2. Unusual Bonding Mode for a Squarato-Bridged Trinuclear Copper(II) Complex”.
     
  • Massoud, S. S.; Mautner, F. A.; Vicente R.; Gallo, A. A.; Ducasse, E. Eur. J. Inorg. Chem. 2007, 1091-1102. “Dinuclear and Polynuclear Bridged Azido-Nickel(II) Complexes. Synthesis, Structure Determination and Magnetic Properties”.