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Wu Xu, Ph.D.

Associate Professor

Montgomery Hall, Room 138 or 236(lab)

P.O. Box 43700
Lafayette LA 70504
337-482-5684
wu.xu@louisiana.edu
Fax: 337-482-5676
http://www.ucs.louisiana.edu/~wxx6941/

Professional Career

Associate Professor, August, 2013 – present, Department of Chemistry, College of Sciences, University of Louisiana at Lafayette
Tenured, University of Louisiana at Lafayette, 2012
Assistant Professor, Department of Chemistry, University of Louisiana at Lafayette, 2006 - 2013
Postdoctoral Research Associate, Department of Biochemistry, St. Jude Children’s Research Hospital, Memphis, TN, 2002 – 2006

Education

Ph.D., Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, 2001
M.S., Bioinformatics and Computational Biology, Iowa State University, 2003

Research Interests

The regulation of gene expression by specific DNA-binding transcription factors is critical for many developmental and physiological processes. Transcription factors interact physically and functionally with coactivators (or co-repressors) and the RNA polymerase II machinery to enhance (or repress) tissue- and signal-specific gene transcription following binding to their target promoters or enhancers (or repressor/silencing elements). The broad objective of my research is to study mechanisms by which signal transduction pathways and gene regulation control cell growth, proliferation, differentiation, death and disease. Specifically, I am interested in understanding protein function and structure relation in the context of signal transduction pathway using experimental and theoretical approaches.

Representative Publications

  • Yuqing Wei and Wu Xu. Application of Traditional Chinese Medicine in Cancer Treatment. Jacobs Journal of Molecular and Translational Medicine 1(1):006, 2015
     
  • Xiao-Jun Xie, Fu-Ning Hsu, Xinsheng Gao, Wu Xu, Jian-Quan Ni, Yue Xing, Liying Huang, Hao-Ching Hsiao, Haiyan Zheng, Chenguang Wang, Yani Zheng, Alus M. Xiaoli, Fajun Yang, Sarah E. Bondos, and Jun-Yuan Ji. CDK8-Cyclin C Mediates Nutritional Regulation of Developmental Transitions through the Ecdysone Receptor in Drosophila. PLOS Biology 13(7):e1002207, 2015
     
  • Liyan Gao, Haitao Ge, Xiahe Huang, Kehui Liu, Yuanya Zhang, Wu Xu and Yingchun Wang. Systematically Ranking the Tightness of Membrane Association for Peripheral Membrane Proteins. Molecular and Cellular Proteomics 14:340-353, 2015
     
  • Wu Xu, Benjamin Amire-Brahimi, Xiaojun Xie, Liying Huang, Junyuan Ji. All-atomic Molecular Dynamic Studies of Human CDK8: Insight into A-loop, Point Mutations and Binding with Its Partner CycC. Computational Biology and Chemistry 51:1-11, 2014.
     
  • Junlei Sun, Sijie Hao, Matthew Radle, Wu Xu, Ivan Shelaev, Victor Nadtochenko, Vladimir Shuvalov, Alexey Semenov, Heather Gordon, Art van der Est and John H. Golbeck. Evidence that Histidine Forms a Coordination Bond to the A0A and A0B Chlorophylls and a Second H-Bond to the A1A and A1B Phylloquinones in M688HPsaA and M668HPsaB Variants of Synechocystis sp. PCC 6803. Biochimica et Biophysica Acta 1837:1362-1375, 2014.
     
  • Carrie Eckert, Wu Xu, Wei Xiong, Sean Lynch, Justin Ungerer, Ling Tao, Ryan Gill, Pin-Ching Maness, and Jianping Yu. Ethylene-forming enzyme and bioethylene production. Biotechnology for Biofuels 7(33):1-11, 2014.
     
  • Liyan Gao, Chunting Shen, Libing Liao, Xiahe Huang, Kehui Liu, Wei Wang, Lihai Guo, Wenhai Jin, Fang Huang, Wu Xu, and Yingchun Wang. Functional proteomic discovery of Slr0110 as a central regulator of carbohydrate metabolism in Synechocystis sp. PCC 6803, Molecular and Cellular Proteomics 13:204-219, 2014.
     
  • Wu Xu, Liquan Xue, Yi Sun, Aline Henry, Jennifer M. Battle, Mathieu Micault, and Stephan W. Morris. Bcl10 Is An Essential Regulator for A20 Gene Expression, Journal of Physiology and Biochemistry 69:821-834, 2013.
     
  • Wu Xu, Jun-Yuan Ji. Dysregulation of CDK8 in tumorigenesis, Journal of Genetics and Genomics, 38:439-452, 2011.
     
  • Wu Xu, Yingchun Wang, Eric Taylor, Amelie Laujac, Liyan Gao, Sergei Savikhin and Parag R. Chitnis. Mutational analysis of photosystem I of Synechocystis sp. PCC 6803: the role of four conserved aromatic residues in the j-helix of PsaB. PLoS One, 6(9): (e24625)1-11, 2011.
     
  • Yuemin Liu, Gallo A. August, Rakesh K. Bajpai, Andrei Chistoserdov, Andrew T. Nelson, Leah N. Segura, and Wu Xu. The Diversity and Molecular Modeling Analysis of B12-dependent and B12-independent Glycerol Dehydratases, International Journal of Bioinformatics and Research Application, 6(5) 484-507, 2010.
     
  • Yuemin Liu, August A. Gallo, Jan Florian, Yen-Shan Liu, Sandeep Mora, and Wu Xu. QM/MM (ONIOM), Study of Glycerol Binding and Hydrogen Abstraction by the Coenzyme B12-Independent Dehydratase, J. Phys. Chem. B, 114:5497-5502, 2010.
     
  • Radhey S. Srivastava, Frank R. Fronczek, Richard S. Perkins, Tomofusa Fukuyama and Wu Xu. Anticancer activities of the ruthenium carboxylato, amido and pyridine complexes, International Journal of Oncology, 36:1591-1598, 2010.
     
  • Yingchun Wang, Wu Xu and Parag R. Chitnis. Identification and bioinformatic analysis of the peripheral and integral membrane proteins of Synechocystis sp. PCC 6803, Proteome Science, 7:11, 1-12, 2009.
     
  • Wu Xu, Febee R. Louka, Pierre E. Doulain, Caroline A. Landry, Franz A. Mautner, Salah S. Massoud. Hydrolytic cleavage of DNA promoted by cobalt(III)–tetraamine complexes: Synthesis and characterization of carbonatobis[2-(2-pyridylethyl)]-(2-pyridylmethyl)aminecobalt(III) perchlorate, Polyhedron 28:1221-1228, 2009.
     
  • Wu Xu, Lawryn H. Kasper, Stephanie Lerach, Trushar Jeevan and Paul K. Brindle. CREB-target genes dictate usage of at least three distinct cAMP-responsive coactivation mechanisms, The EMBO Journal 26:2890-2903, 2007.
     
  • Wu Xu, Tomofusa Fukuyama, Paul Ney, Demin Wang, Jerold Rehg, Kelli Boyd, Jan M.A. van Deursen, and Paul K. Brindle. Global transcriptional coactivators CREB-binding protein and p300 are essential for mouse B-cells in vivo, Blood 107(11):4407-4416, 2006.
     
  • Wu Xu, Parag R. Chitnis, Alfia Valieva, Art van der Est, Klaus Brettel, Mariana Guergova-Kuras, Yulia N. Pushkar, Stephan G. Zech, Dietmar Stehlik,Gaozhong Shen, Boris Zybailov, and John H. Golbeck. Electron Transfer in Cyanobacterial Photosystem I: II. Determination of Forward Electron Transfer Rates of Site-directed Mutants in a Putative Electron Transfer Pathway from A0 through A1 to FX, The Journal of Biological Chemistry 278:27876-27887, 2003.
     
  • Wu Xu, Parag Chitnis, Alfia Valieva, Art van der Est, Yulia N. Pushkar ,Maciej Krzystyniak, Christian Teutloff, Stephan G. Zech, Robert Bittl, Dietmar Stehlik, Boris Zybailov, Gaozhong Shen, and John H. Golbeck. Electron Transfer in Cyanobacterial Photosystem I: I. Physiological and Spectroscopic Characterization of Site-directed Mutants in a Putative Electron Transfer Pathway from A0 through A1 to FX, The Journal of Biological Chemistry 278:27864-27875, 2003.