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Siva Murru, Ph.D.

Research Scientist/Adjunct Faculty

Montgomery Hall, Room 209

P.O. Box 43700
Lafayette LA 70504
337-482-1063
sivam@louisiana.edu

Education:

Ph. D. Chemistry, Indian Institute of Technology (IIT) Guwahati, India, 2010
M.S. Chemistry, Acharya Nagarjuna University, India, 2005.
B.S. Chemistry, Andhra University, India, 2003.

Professional Experience:

Research Scientist: Department of chemistry, University of Louisiana at Lafayette, LA. (2013 – Present)
Adjunct Faculty: Department of chemistry, University of Louisiana at Lafayette, LA. (2014 – Present)
Postdoctoral Research Scientist: Division of chemistry, Torrey Pines Institute for Molecular Studies, FL. (2012 – 2013)
Postdoctoral Research Associate: Department of chemistry, University of Louisiana at Lafayette, LA. (2010 – 2012)
Visiting Scholar: Chemistry division, Institut de Chimie Moléculaire de Reims (ICMR), CNRS - Université de Reims, France. (2008)

Research Interests:

Our research involves in the design and development of novel catalytic approaches for the synthesis of organo nitrogen compounds and N,O-heterocycles. We are particularly interested in developing transition metal catalyzed C-N (carbon-nitrogen) and C-C (carbon-carbon) bond forming processes that ultimately leads to heterocycles and biologically relevant molecules. In order to understand the reaction mechanisms, we identify (or isolate) intermediate complexes that gives insight into the origins of selectivity and governs optimization towards the development of most efficient synthetic protocols. The compounds synthesized in our laboratory are being evaluated for anti-bacterial activity.

Major areas of my research include Transition metal catalysis, Heterocyclic synthesis, Asymmetric catalysis, Organometallics, and Medicinal chemistry.

Major components of training for students: Synthetic experiments, Chromatographic separations, Instruments handling, Data analysis, Research philosophy and Safety.

Representative Publications:

  • Fe-catalyzed Direct α C-H Amination of 1,3-Dicarbonyl Compounds and 2-Oxindoles; Siva Murru; Charles Seth; Radhey S. Srivastava. Org. Lett. 2015, 17, 2122.
     
  • Synthesis of Substituted Quinolines via Allylic Amination and Intramolecular Heck-Coupling; Siva Murru; Brandon McGough; Radhey S. Srivastava. Org. Biomol. Chem. 2014, 12, 9133. (cover-page article: http://pubs.rsc.org/en/content/articlepdf/2014/ob/c4ob90163k)
     
  • Iron-Catalyzed Allylic C-H Amination of Substituted 1,3-Dienes; Siva Murru; Radhey S. Srivastava. Eur. J. Org. Chem. 2014, 10, 2174. (Highlighted in Organometallic Chemistry News, March 31st 2014)
     
  • Combinatorial Synthesis of Oxazol-Thiazole Bis-Heterocyclic Compounds; Siva Murru, Adel Nefzi. ACS Comb. Sci. 2014, 16, 39.
     
  • Parallel Synthesis of Bis-Oxazole Peptidomimetics; Siva Murru, Colette Dooley, Adel Nefzi. Tetrahedron Lett. 2013, 54, 7062.
     
  • Direct Synthesis of β-alkyl N-Aryl Aza Baylis-Hillman Adducts via Nitroso-Ene Reaction; Siva Murru, August A. Gallo, Radhey S. Srivastava. J. Org. Chem. 2012, 77, 7119.
     
  • Copper-catalyzed Direct Synthesis of 3-Aryl Indoles; Siva Murru, August A. Gallo, Radhey S. Srivastava. Eur. J. Org. Chem. 2011, 11, 2035.
     
  • Gold-catalyzed Synthesis of Indoles via Annulation of Nitrosoarenes and Alkynes; Siva Murru, August A. Gallo, Radhey Srivastava. ACS Catal. 2011, 1, 29.

Patents:

Method of Producing Chiral N-­Substituted Allyl Amine Compounds, R. S. Srivastava, Siva Murru. US Patent 2015 (pending)