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Radhey S. Srivastava, Ph.D.

Professor

Montgomery Hall, Room 215

P.O. Box 43700
Lafayette LA 70504
Phone: 337-482-5677
rss@louisiana.edu
http://www.ucs.louisiana.edu/~rss1805/

Education:

B.S., University of Gorakhpur.
Ph.D., University of Gorakhpur.
Diploma, Organometallic Chemistry, Tokyo Institute of Technology, Japan.

Research Interest:

Organometallic: Transition Metal-catalyzed Nitrogenation of Hydrocarbons. We discovered that Cu-salts and related complexes catalyze olefins with arylhydroxylamine to produce allyl amines. The reactions occur with remarkable regioselectivity with respect to the alkene and the products are valuable as synthetic intermediates and bioactive targets. Most recently, we discovered asymmetric allylic mination catalyzed by Cu.

Medicinal Inorganic Chemistry: Ruthenium-based Metallopharmaceuticals Primarily we are tackling problems related to the synthesis of ruthenium complexes with various heterocyclic amines and their assay on various cancer cell-lines. Another area of development in medicinal inorganic chemistry is the development of ruthenium-based anticancer drugs and strategy to overcome drug resistance.

Renewable Biomass Energy: Metal-catalyzed Conversion of Cellulosic Biomass for fuels and value-added chemicals We aim to develop new more robust and economically viable catalytic systems for efficient, selective, economical deoxydehydration reactions of cellulosic biomass. Reactivity studies will test the effectiveness of the new reductants and catalysts, identify and quantify the reaction products, and use this information to develop new processes for valuable products and fuels.

Selected Recent Publications and Patents:

  • S. Murru, C. S. Lott, B. McGough and R. S. Srivastava,”Fe-Catalyzed Synthesis of Substituted N-Aryl Oxazolidines and N-Aryl Amino Alcohols.” Organic & Bimolecular Chemistry, 2016, 14, 3681.
     
  • S. Murru, C. S. Lott, F. R. Fronczek, R. S.  Srivastava, “Fe-Catalyzed Direct α C-H Amination of Carbonyl Compounds”, Org. Lett. 2015, 17, 2122-2125.
    Siva Murru, Brandon McGough, R. S.  Srivastava,” Synthesis of Substituted Quinolines via Allylic Amination and Intramolecular Heck-Coupling”, Organic & Bimolecular Chemistry, 2014, 12, 9133. (cover-page article)
     
  • J. Davis, R. S. Srivastava, “Oxorhenium-Catalyzed Deoxydehydration of Cellulosic Biomass”, tetrahedron Lett. 2014, 55, 4178.
     
  • S. Murru, R.S. Srivastava, “Iron-Catalyzed Selective Allylic C-H Amination of substituted 1,3-Dienes”, Eur. J. Org. Chem , 2014, 2174-2181 (Highlighted in http://organometallicchemistrynews.blogspot.com/2014/03/iron-catalyzed-a...)
     
  • S. Murru, August A. Gallo and R.S. Srivastava,” Direct synthesis of ß-alkyl N-Aryl Aza Baylis-Hillman Adducts via Nitroso-Ene reaction”, J. Org. Chem. 2012, 77, 7119.
     
  • S. Murru, K.M. Nicholas and R.S. Srivastava,” Ruthenium (II) Sulfoxide-Catalyzed Hydrogenolysis of Glycols and Epoxides, J. Mol. Catalysis A, 2012, 364-365, 460- 464.
     
  • Solene David, R. S. Perkins, F. R. Fronczek, S. Kasiri, S. S. Mandal and R. S. Srivastava, Synthesis, characterization, and anticancer activity of ruthenium pyrazole complexes, J. Inorg. Biochem. 2012, 111, 33-39.
     
  • S. Stanowski, K. M. Nicholas and R. S. Srivastava,” [Cp*Ru(CO)2]2-Catalyzed Hydrodeoxygenation and Hydrocracking of Diols and Epoxides”, Organometallics, 2012, 31, 515-518.
     
  • R. S. Srivastava, Roy Bertrand III , A. A. Gallo and K.M. Nicholas,”Cu(I)/Cu(II)- catalyzed allylic amination of alkenes, Tetrahedron Lett. 2011, 52, 3478. 6. S. Murru, A.A. Gallo, R.S. Srivastava,” Copper-catalyzed direct synthesis of 3- Arylindoles”, Eur. J. Org. Chem., 2011, 2035.
     
  • S. Murru, A.A. Gallo, R.S. Srivastava,” Gold-catalyzed Synthesis of 3-arylindoles via Annulation of Nitrosoarenes and Alkynes’, ACS catalysis 2011, 1(1), 29-31.
     
  • R. S. Srivastava, F. R. Fronczek, R. S. Perkins, T. Fukuyama and Wu Xu, “Anticancer Activities of Ruthenium (II, III) Carboxylato, Amido and Pyridine Complexes”, Int. J. Oncology, 2010, 36, 1591-1598.
     
  • R. S. Srivastava, N.R. Tarver and K. M. Nicholas, Mechanistic Studies of Copper(I)Catalyzed Allylic amination, J. Am. Chem. Soc, 2007, 129, 15250.

Patents:

R.S. Srivastava and S. Murru,” Method of Producing Chiral N-substituted Allyl Amine Compounds”, United States Patent and Trademark office, (United States Patent and Trademark Office # 14/418,540).

Major Funding:

  1. NSF, Studies on Catalytic Asymmetric C-H Amination of Alkenes Studies on Catalytic Asymmetric C-H Amination of Alkenes.   
     
  2. NIH, Enantioselective C-H Amination of Alkenes and Carbonyl Compounds and Novel Application Thereof.
     
  3. Louisiana Board of Regents, Metal- Transition-metal catalyzed asymmetric nitrogenation of hydrocarbons (olefins): Method development and its synthetic applications to valuable chemicals, $225,000.
     
  4. Louisiana Board of Regents: Metal-catalyzed group transfer reactions, $260,000.

For more information:

http://www.ucs.louisiana.edu/~rss1805/